Abstract
The objective of this thesis project is to synthesize 1,2-disubstituted cyclopropene compounds from internal alkynes and diazoacetate compounds via (2÷1] cycloaddition reactions catalyzed by rhodium acetate (Rh2(OAc)4). To date, there is no known synthetic transformation to achieve this substitution pattern. 1,2-disubstituted cyclopropene compounds are versatile synthetic intermediates because their functionalization enables further synthetic manipulation. In this work, three cyclopropene compounds were synthesized using this methodology. Their syntheses are described herein.
Library of Congress Subject Headings
Organic compounds--Synthesis; Cytoalkenes
Publication Date
8-2010
Document Type
Thesis
Student Type
Graduate
Degree Name
Chemistry (MS)
Department, Program, or Center
School of Chemistry and Materials Science (COS)
Advisor
Michael Coleman
Advisor/Committee Member
Christina Collison
Advisor/Committee Member
Paul Craig
Recommended Citation
Higgins, Kate E., "Synthesis of Polyfunctionalized 1,2-Disubstituted Cyclopropene Compounds" (2010). Thesis. Rochester Institute of Technology. Accessed from
https://repository.rit.edu/theses/9127
Campus
RIT – Main Campus
Plan Codes
CHEM-MS
