Abstract

Most research has been conducted on the structure and function of many individual genes as well as complementary proteins. Many of these studies look at specific population groups' country of origin, geographic location, or ethnicity but do not correlate findings between these groups. In this project I attempted to associate the structural and functional consequences of individual mutations in Human BRCA1 to other organisms. My findings suggest a strong correlation between human geographical isolation and mutation exclusivity. Furthermore strong sequence and mutation conservation as well as structural homology exist between many species.

Library of Congress Subject Headings

BRCA genes--Research; Human genetics; Mutation (Biology)

Publication Date

1-2007

Document Type

Thesis

Student Type

Graduate

Degree Name

Bioinformatics (MS)

Department, Program, or Center

Thomas H. Gosnell School of Life Sciences (COS)

Advisor

Gary R. Skuse

Advisor/Committee Member

Richard L. Doolittle

Comments

Physical copy available from RIT's Wallace Library at RC268.44.B73 W76 2007

Campus

RIT – Main Campus

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