Amgad Khalil

Abstract

The purpose of this research was to evaluate an alternative to polyvinyl chloride based packaging materials for pharmaceutical blister packaging that is neither harmful to the environment nor corrosive to the equipment used in pharmaceutical packaging. Olefin structures (PP/COC/PP) were tested and compared to halogen based material (PVC/PVDC) using the following criteria: • Moisture Vapor Transmission Rate (MVTR) • Vacuum leak test • Peel strength test • Machine ability and form-ability on an Uhlmann UPS4 thermoformer • Layer distribution • Financial impact Cyclic Olefin Copolymers (COC) was proven to have the properties required to adequately protect the product while being environmentally safer than PVDC and CTFE.

Library of Congress Subject Headings

Polyolefins; Plastic films; Blister packs; Plastics in packaging; Drugs--Packaging; Polyvinyl chloride--Environmental aspects; Drug packaging industry--Environmental aspects

Publication Date

2004

Document Type

Thesis

Student Type

Graduate

Degree Name

Packaging Science(MS)

Department, Program, or Center

Packaging Science (CAST)

Advisor

Deanna Jacobs

Advisor/Committee Member

Craig Densmore

Advisor/Committee Member

Daniel Goodwin

Comments

“I, Amgad Khalil, prefer to be contacted each time a request for reproduction is made.” Physical copy available from RIT's Wallace Library at TP1180.P67 K42 2004

Campus

RIT – Main Campus

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