Abstract

Pharmaceutical inhalation aerosol technology has become an important therapy for the treatment of both respiratory and non-respiratory illness. Targeting therapeutic aerosols to the small airways of the lung can effectively treat many of these diseases. Delivery of the therapeutic agent directly to the site of action, for cases involving respiratory diseases, ensures an adequate therapeutic level of the drug is reached, without leading to side effects due to high systemic concentrations. For non-respiratory diseases, the periphery of the lung offers enormous surface area (approximately 100m2) for rapid absorption into circulation. In either case, the appropriate spray characteristics (0.5 um

Library of Congress Subject Headings

Turbulence; Nozzles--Fluid dynamics; Fluid mechanics; Spraying; Atomization; Aerosol therapy

Publication Date

2002

Document Type

Thesis

Department, Program, or Center

Mechanical Engineering (KGCOE)

Advisor

Robinson, Risa

Advisor/Committee Member

Wellin, John

Advisor/Committee Member

Kozak, Jeffrey

Comments

Note: imported from RIT’s Digital Media Library running on DSpace to RIT Scholar Works. Physical copy available through RIT's The Wallace Library at: TA357 .M435 2002

Campus

RIT – Main Campus

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