Abstract
Modulation of kidney cyclic AMP pdase by diuretics and antihypertensives was studied. It was found that spironolactone activates pdase and that furosemide, ethacrynic acid, triameterine , quinethazone, metolazone, chlorothiazide, propranolol and hydralazine, inhibit pdase. The relative tissue specificity (medulla or cortex) for some of the compounds appears to be in agreement with the proposed sites of drug action via pharmocological mechanisms which do not involve Inter action with cAMP pdase . The specific activity of pdase in the medulla was found to be double that in the cortex. Pdase was found to be a complex enzyme with at least two separate sets of kinetic parameters.
Library of Congress Subject Headings
Hypotensive agents; Renal pharmacology; Diuretics
Publication Date
4-1-1977
Document Type
Thesis
Department, Program, or Center
School of Chemistry and Materials Science (COS)
Advisor
Bigler, William
Recommended Citation
Fouquet, Gary, "Modulation of cyclic amp phosphodiesterase" (1977). Thesis. Rochester Institute of Technology. Accessed from
https://repository.rit.edu/theses/4898
Campus
RIT – Main Campus
Comments
Note: imported from RIT’s Digital Media Library running on DSpace to RIT Scholar Works. Physical copy available through RIT's The Wallace Library at: RM375.F68