Studies toward the total synthesis of eletefine

Author

Ijaz Ahmed

Abstract

A method towards the total synthesis of eletefine is described. Two related convergent syntheses are explained which divide the molecule into two fragments. Improvements towards the synthesis of a bis-functionalized isoquinoline fragment are explained. Expansion on the knowledge and understanding of the isoquinoline system is also described. The synthesis illustrated entails a bromination of a triflate functionalized isoquinoline system and a regio-selective Sonogashira reaction. Suggestions towards the completion of the total synthesis are prescribed.

Library of Congress Subject Headings

Bromination; Alkaloids--Synthesis; Isoquinoline

Publication Date

7-1-2010

Document Type

Thesis

Department, Program, or Center

School of Chemistry and Materials Science (COS)

Advisor

Cody, Jeremy

Advisor/Committee Member

Rosenberg, Paul

Comments

Note: imported from RIT’s Digital Media Library running on DSpace to RIT Scholar Works. Physical copy available through RIT's The Wallace Library at: QD281.B7 A46 2010

Recommended Citation

Ahmed, Ijaz, "Studies toward the total synthesis of eletefine" (2010). Thesis. Rochester Institute of Technology. Accessed from
https://repository.rit.edu/theses/3705

Campus

RIT – Main Campus