Abstract

Renal physiology, particularly the process of glomerular filtration, remains one of the most conceptually challenging topics in medical education due to its microscopic scale, dynamic pressure relationships, and structural complexity. Understanding how plasma passes through the glomerular filtration barrier requires spatial reasoning across multiple levels—from the gross anatomy of the kidney to the ultrastructure of capillaries, podocytes, and the glomerular basement membrane. This thesis addresses these challenges through the development of a scientifically accurate three-dimensional (3D) animation that illustrates glomerular filtration within its anatomical and physiological context. Designed as a visual teaching aid, the animation aims to improve comprehension of renal microanatomy, demonstrate the functional relationship between structure and process, and depict both normal and pathological filtration dynamics.  Development began with an extensive review of primary anatomical and physiological sources, including Brenner and Rector’s The Kidney (9th ed.) and Gray’s Anatomy: The Anatomical Basis of Clinical Practice (41st ed.), supplemented by recent research on glomerular barrier function. Conceptual sketches synthesized spatial relationships and established consistent color conventions before 3D modeling. Anatomical assets—including the glomerular capillary tuft, podocytes, Bowman’s capsule, and renal tubules—were primarily sculpted in ZBrush, while Autodesk Maya was used for animation and rendering. Procedural systems such as MASH, nParticles, and lattice deformers simulated blood flow, filtrate movement, and barrier disruption. Final compositing and narration were completed in Adobe After Effects, integrating narration, labeling, and sound design to create a cohesive visual narrative.  The completed animation presents glomerular filtration from both normal and pathological perspectives, visualizing the delicate balance of forces and structures that sustain renal function. By combining anatomical accuracy, educational design, and aesthetic clarity, the project transforms an abstract physiological process into a clear and tangible experience. This work demonstrates how biomedical visualization can enhance engagement and comprehension in renal physiology education while underscoring the broader potential of 3D animation as a tool for teaching complex biological systems.

Publication Date

1-2026

Document Type

Thesis

Student Type

Graduate

Degree Name

Medical Illustration(MFA)

Department, Program, or Center

Medical Illustration

College

College of Health Sciences and Technology

Advisor

Craig Foster

Advisor/Committee Member

Benjamin Folgelgren

Advisor/Committee Member

James Perkins

Campus

RIT – Main Campus

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