Abstract

Streptococcus sobrinus (SSO) is a pathogenic microbe native to the human oral microbiome. SSO is historically implicated in carie formation, and may be involved in neurodegenerative disease progression. The study of SSO is challenged by a lack of access to a serotyping assay. This study aims to identify sero-specific candidates from available SSO genomes using sequence alignment and phylogenetic analysis. Three candidate genes were found that may be sero-specific: putative quinol monoxygenase, a hypothetical protein, and elongation factor Tu. To further assess the candidates the original antibodies or a list of proteins involved is required. Alternatively, a new classification system should be developed to replace the concept of serology for SSO exclusively.

Publication Date

12-16-2025

Document Type

Thesis

Student Type

Graduate

Degree Name

Bioinformatics (MS)

Department, Program, or Center

Thomas H. Gosnell School of Life Sciences

College

College of Science

Advisor

Robert Osgood

Advisor/Committee Member

Elle Barnes

Advisor/Committee Member

Feng Cui

Campus

RIT – Main Campus

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