Abstract

Bioheat transfer is the study of heat transfer in biology. There are several sources of heat in biology including external ones such as surgical applications of heat, or internal ones like cancer tissue. Blood flow networks affect both types of processes and are often generated during disease phenomenon through a process called angiogenesis. This affects the properties of the tissue. Several attempts were made to model flow and heat transfer within various tissues through physical measurements or computer simulations. Both types of models used bioheat transfer models do not consider the geometry of vasculature at its most fundamental level. The objectives of the research are to consider blood vessel diameter, length and flow direction to determine how each impacts the effective thermal conductivity in live tissues. This work used Computational Fluid Dynamics techniques and anatomical properties of blood vessels to create a parametric study of how non cardiac vasculature affects tissues. Validation was conducted using Gautherie’s data on the effective thermal conductivity of the breast as a case study. The analysis was conducted in both 2D and 3D and extended to include implications of the heat source and multiple vessels on the thermal properties of the tissue.

Publication Date

7-2024

Document Type

Thesis

Student Type

Graduate

Degree Name

Mechanical Engineering (MS)

Department, Program, or Center

Mechanical Engineering

College

Kate Gleason College of Engineering

Advisor

Satish G. Kandlikar

Advisor/Committee Member

Howard Tu

Advisor/Committee Member

Isaac Perez-Raya

Campus

RIT – Main Campus

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