Abstract

Objective: The objective of this paper is to thoroughly research the new treatment options for migraine, including both pharmacologic and non-pharmacologic therapies, and investigate the risk of psychological disorders to migraine. This paper proposes to analyze outcomes of current work on the clinical manifestations, risk factors, and treatment of migraines. Methods (Evidence Acquisition): Keywords such as “migraine headache” and “new treatment” were searched on PubMed which yielded 2,623 results between the years 2003-2023, in which 16 articles were used. After narrowing the search on PubMed to “migraine headache” and “psychological comorbidities”, 261 results appeared, and 2 articles used. Other scholarly resources including Science Direct and Web of Science were used. Evidence Synthesis: Multiple RCTs, case studies, and clinical reviews were analyzed to investigate if psychological disorders are correlated with migraine and to determine what new migraine treatments are available and effective. The articles supported the correlation between migraine and psychological disorders along with how symptoms can worsen because of comorbidities. New treatment options such as 5-hydroxytrptamine1F receptor agonists and calcitonin gene-related peptide antagonists were effective alternatives to mainstay treatment. Botox treatment is shown to reduce the intensity and frequency of chronic migraine. Exercise and diet control are non-pharmacologic treatments that have been as effective as preventive and abortive therapies for migraines. Conclusion: Psychological disorders should be recognized as a risk factor and comorbidity for onset and chronicity of migraine. New treatments, both pharmacologic and non-pharmacologic, should be acknowledged in the clinical setting to allow more treatment options for all types of migraine.

Publication Date

1-1-2024

Document Type

Master's Project

Student Type

Graduate

Degree Name

Physician Assistant (MS)

Department, Program, or Center

Physician Assistant

College

College of Health Sciences and Technology

Advisor

Heidi Miller

Campus

RIT – Main Campus

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