This thesis presents methods to increase savings in the global vaccine market without compromising its sustainability. Considering a hypothetically coordinated vaccine market (HCVM), where one or more coordinating entities are responsible for negotiating quantities and prices of vaccines on behalf of countries with different purchasing powers, this work explores four different and complementary issues related to market configurations impacting global affordability and profits: (1) the level of cooperation among coordinating entities; (2) optimal country assignment to coordinating entities; (3) benefits in procuring vaccines through tenders of formularies rather than purchasing doses individually; and (4) the value of a dollar saved in different countries. Additionally, these studies incorporate prescriptive and descriptive analytics with economic theory exploring the incentives that could bring the global vaccine market closer to the HCVM. The findings presented in this thesis contribute both to the literature and to the sustainability of the global vaccine market with specific recommendations to improve affordability for low-income countries with minimal impact to other market segments or to the vaccine producers.

Library of Congress Subject Headings

Vaccines industry--International cooperation; World health; Vaccines--Economic aspects

Publication Date


Document Type


Student Type


Department, Program, or Center

Industrial and Systems Engineering (KGCOE)


Ruben Proano

Advisor/Committee Member

Nasibeh Azadeh-Fard

Advisor/Committee Member

Bharat Bhole


RIT – Main Campus

Plan Codes