Lung adenocarcinoma is the most frequently diagnosed subtype of lung cancer, and while the disease itself can be strenuous, the typical treatments such as chemotherapy are also known to cause whole body harm to the patient due to its systemic nature. Target therapies are increasingly gaining popularity for their ability to selectively apply the therapy to a specific cell. In terms of cancer, this method would lessen some, if not all the painful side-effects of chemotherapy and enhance a patient’s quality of life. Narrowing down what genes are deemed to be essential to the operation of the cell can help determine which gene-gene interactions would make prime candidates for further target therapy research. This project aimed to develop a cross referencing method using literature-minded and RNASeq data in order to identify essential gene-gene relations unique to lung adenocarcinoma cell lines. In doing so, two gene-gene relations with significant changes in gene expression values across all cell lines under chemotherapeutic conditions were successfully discovered. These relations can be used in future research to study as potential treatment targets to include alongside chemotherapy with the possibility to alleviate the severe side effects that the patients currently undergo with standard treatment.
Library of Congress Subject Headings
Lungs--Cancer--Treatment; Adenocarcinoma; Drug targeting; Nucleotide sequence
Department, Program, or Center
Thomas H. Gosnell School of Life Sciences (COS)
Gary R. Skuse
Pridmore, Mariel V., "Identification of Essential Gene Relations For Lung Adenocarcinoma Therapy Targets by Cross-Referencing Literature-Mined and RNASeq Data" (2022). Thesis. Rochester Institute of Technology. Accessed from
RIT – Main Campus